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Endophenotype Research in Psychiatric Genetics: Genetic architecture and reproducibility

  • Prof. Marcus Munafò
Friday 18 December 2015
Niels Bohrweg 1
2333 CA Leiden
Lorentz Center, 2nd floor

"After over ten years of endophenotype research in psychiatric genetics we have learned some important lessons. Critically, the genetic architecture of endophenotypes is not dramatically different from that of clinical phenotypes, and their utility is likely to lie in elucidating mechanism rather than discovering new genetic associations. Suggestions for improving the reproducibility of endophenotype research will be presented, drawing on lessons from genomics and the recent reproducibility project in psychology."

Lorentz Workshop

This keynote lecture is part of the Lorentz Workshop ‘Endophenotypes of Social Anxiety Disorder – Can We Detect Them and Are They Useful in Clinical Practice?’ (14-18 december 2015 at the Snellius building). This workshop is organized by researchers of Leiden University and the Leiden University Medical Center (LUMC), who are working on the Leiden Family Study on Social Anxiety Disorder.

The Leiden Family Study on Social Anxiety Disorder is a unique family study with a 3-generation genetic design to detect endophenotypes of SAD in extended families ( Leiden Family Lab). In this study, an affected individual with SAD, his or her siblings and children are tested, as well as the partners of each family member. The key question addressed in this project is whether the psychophysiological and neurocognitive abnormalities often reported in SAD patients are heritable, and can thus be found in family members of SAD patients as well. This family project is, to the best of our knowledge, the first comprehensive study aiming to determine endophenotypes of SAD.

Building on the Leiden Family Study, the Lorentz Center workshop ‘Endophenotypes of Social Anxiety Disorder – Can We Detect Them and Are They Useful in Clinical Practice?’ aims to gain more insight into candidate endophenotypes of SAD and their potential relevance for clinical practice. Participants from different traditions and backgrounds contribute to this workshop, in order to establish longer-lasting collaborations and to facilitate collaborations on papers and cross-site grant applications.

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