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Immune modulation in human and animal infections: impact on health, disease and therapy

This 5-day Summer School will focus on immunotherapy, vaccinology, microbiota interventions and drug development for infectious and hyperinflammatory diseases, including novel therapeutic approaches such as host-directed personalized therapies. The overall aim of the course is to give participants an understanding of vaccine design and immunotherapy, preclinical testing, and clinical evaluation.

Immune modulation in human and animal infections

The Themes covered by the Summer School can be summarized as follows:

  • Introduction to current standards in (emerging) infectious disease control
  • The molecular mechanisms of immune modulation by infectious agents
  • Antimicrobial resistance in bacteria, viruses, parasites and fungi and new approaches for treatment of drug resistant microorganisms
  • The role of microbiome in health and disease, both animal and human
  • Controlled human and (large) animal infection models (combined with entrepreneurship)
  • Infectious disease vaccine design and preclinical validation
  • Novel host-directed and personalised therapies for infectious and immune diseases
  • Develop a research proposal in small tutor-guided sessions on a topic related the themes of the Summer School

Learning objectives

The objectives of the course are as follows:

  1. To develop an overall understanding of immune modulation by pathogens and commensals and the balance between immune exploitation and immune training, including the role of the microbiota (benefit).
  2. To give participants the knowledge and skills to design and test a vaccine/immunotherapy for a given infection or disease, including understanding of the immune responses involved, role of adjuvant, target antigen(s) and immune cells.
  3. To understand the role and application of controlled human infections in vaccine and/or immunotherapy development.
  4. To impart knowledge and understanding of manufacture across a spectrum of different vaccines, including the requirements of GMP (Good Manufacturing Practice).
  5. Translate the acquired knowledge into novel research proposals on themes related to One Health.

Participants

This Summer School is particularly suitable for (bio)medical Master students, PhD students, as well as early stage post-doctoral scientists who are interested in one or more of the following; immunology, microbiology and metabolism.

The course is best suited for those interested in increasing their knowledge on human and animal infectious diseases, immunotherapy for inflammatory diseases, microbiota interventions and host-directed therapies against infectious diseases, clinical trials as well the industrial production of vaccines and antimicrobial therapies.

While the course is directed at PhD/graduate students, scientists working in industry may also wish to apply to gain latest insights into immunotherapy and vaccinology. Applicants will be required to provide a CV, some background to the research they are engaged in, a motivation letter and letter of recommendation from their current supervisor. The number of applicants in the course will not exceed 30. 

Applications can be sent to Boerhaavenascholing@lumc.nl.

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