This Week's Discoveries | 1 October 2019
- dinsdag 1 oktober 2019
Niels Bohrweg 2
2333 CA Leiden
- De Sitterzaal
Please note that, due to the new lecture schedule, the start and end time of This Week's Discoveries have been changed.
Conquering the fortress: new strategies for the treatment of tuberculosis
Monica is a Veni laureate in the group of Prof. Annemarie Meijer at the IBL. She is interested in host-pathogen interactions and in studying how pathogens manipulate inflammatory and cell death-related pathways within host cells.
Tuberculosis is a major public health issue. The bacteria causing tuberculosis live and hide inside granulomas, a fortress. Antibiotics have difficulties to reach and kill the pathogen when living inside granulomas, resulting in an increased appearance of drug-resistant bacteria. Alternative therapies for tuberculosis are therefore desperately needed.
Therapies directed at the host (host-directed therapy) instead of the pathogen provide such an alternative. For instance, by disrupting cellular pathways of crucial importance for the course of the infection.
In this talk, I will present some of the results obtained in the last years that have led to an NWO Veni grant for exploring new host-directed strategies for the treatment of tuberculosis.
To be announced.
Simon is professor of Numerical star dynamics at Leiden Observatory. His research interests lie with Computational Gravitational Dynamics, Stellar and Binary Evolution, Galaxy Dynamics, Modeling Dense Stellar Systems, Supermassive Black Holes, Binary Population Synthesis and High-performance Computing.
To be announced.