Universiteit Leiden

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This Week's Discoveries | 7 May 2019

  • Barbara Terhal
dinsdag 7 mei 2019
Niels Bohrweg 2
2333 CA Leiden
De Sitterzaal

First lecture

Kick-starting drug development; translational systems pharmacology using innovative zebrafish experiments and advanced computational modelling

Rob van Wijk (LACDR)
Rob is a PhD candidate at the division of Systems Biomedicine and Pharmacology of the Leiden Academic Centre for Drug Research (LACDR). His research crosses borders between different disciplines, for example pharmacology, analytical chemistry, computer science, and biology. Currently he is collaborating with two other departments of Leiden University, as well as with national (VUmc) and international (Uppsala, Harvard) universities.

In early drug development, zebrafish and specifically the zebrafish larvae are increasingly popular as vertebrate model organism. They can serve as a link between in vitro experiments and in vivo studies and their high-throughput potential allows for the generation of large amounts of data [1]. Translation of these pharmacological findings to higher vertebrate species however requires the development of novel pharmacokinetic-pharmacodynamic (PKPD) experimental methods and computational concepts. Here, we present two examples illustrating the challenges in achieving this.

Second lecture, Lorentz Center highlight Lecture

Escaping Heisenberg uncertainty

Barbara Terhal (TU Delft)
Barbara is a professor at the EEMCS Department at the TU Delft and a staff member at QuTech since 2017. She received her PhD degree Cum Laude from the University of Amsterdam in 1999 on “Quantum Algorithms and Quantum Entanglement”, making her the first person to get a PhD in quantum computing in the Netherlands. She is one of the organizers of the workshop Mathematics of Quantum Information Theory that is being held in the Lorentz Center from 6 May through 10 May 2019.

One of the lessons of quantum mechanics is that we cannot measure the position and momentum of a particle simultaneously.

Surprisingly, this does not preclude being able to determine modular values for its position and momentum simultaneously. We explain how this is possible and how recent experiments with the motional state of a trapped-ion qubit can lead to a first implementation of this idea.

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