Universiteit Leiden

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Joan van der Waals colloquium

vrijdag 10 mei 2019
Drinks afterwards.
Niels Bohrweg 2
2333 CA Leiden
De Sitterzaal

How fast are functional motions of protein machines? A single-molecule perspective

Protein machines carry out multiple tasks in the cell, but their modes of operation are still quite obscure. Single-molecule fluorescence spectroscopy is a powerful tool for exposing function-related motions of such nanomachines. We recently developed novel methodology that allows us to track protein dynamics even on the microsecond time scale. In the lecture, I will show how this analysis helped us understanding the dynamics of two different machines. Surprisingly, internal motions are found to be faster than chemical steps by 2-3 orders of magnitude, which we will try to rationalize in the lecture.

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