Universiteit Leiden

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Lezing | Van Leeuwenhoek Lecture on BioScience

Myosin motors drive cytoplasmic streaming, cell growth and plant development

  • Valerian Dolja (Oregon State University, Department of Botany and Plant Pathology, Genome Research and Biocomputing)
donderdag 11 april 2019
Einsteinweg 55
2333 CC Leiden

Let op: deze lezing is in het Engels


You are welcome from 15.45 onwards, we have tea, coffee and biscuits. After the lecture there will be drinks.

In this lecture, Valerian Dolja will discuss a general concept of myosin-powered transport and its contributions to plant biology based on the most recent experimental data available in this field.

It was long assumed that the exceptionally vigorous intracellular dynamics in plants, the cytoplasmic streaming, is powered by myosins. However, neither exact biological role of streaming nor its molecular mechanisms were elucidated until the last decade. Using genetic, imaging and biochemical approaches, Dolja and his team have demonstrated critical roles of plant myosins in actin cytoskeleton morphology, polarized and diffuse cell growth and plant development. They have also identified a novel vesicular compartment defined by myosin receptors of MyoB  family that appears to be the magic driver of cytoplasmic streaming.

Furthermore, they described two novel families of myosin adaptors the most enigmatic of which is targeted to nucleus. A spectrum of plant myosin functions was further expanded by a discovery of myosins’ involvement in cell division and cell plate growth made in collaboration with an Israeli team.

About Valerian Dolja

Valerian Dolja studied Biochemistry  and obtained a PhD (1980) in Molecular Biology at Moscow State University. He holds a D.Sc in Virology (1987, Moscow State University). He had positions at the Department of Virology and  the Institute of Physico-Chemical Biology in Moscow. From 1991-1994 he was a senior research scientist at the department of Biology at Texas, A&M University. After that he moved to Oregon State University, where in 2001 he became appointed as Professor of Botany & Plant Pathology.

His major research interests are:

  • Plant Cell Biology (endomembrane transport by molecular motors)
  • Functional, comparative and evolutionary genomics of viruses
  • Plant Biotechnology (RNA viruses as gene expression and RNAi vectors)

He published over 140  articles, holds two US patents and was invited as a speaker at many national and international meetings. He received many honors and awards.

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