Universiteit Leiden

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Lezing

This Week’s Discoveries | 18 December 2018

Datum
18 december 2018
Tijd
Bezoekadres
Oort
Niels Bohrweg 2
2333 CA Leiden
Zaal
De Sitterzaal

Title                                     
Host immune adaptations to microbial colonization

Speaker
Bjørn Koch (IBL)

Bjørn Koch is a Molecular Biologist in the Animal Sciences & Health cluster at the IBL. In his work he focuses on all aspects of host-microbe interactions, both pathogenic and beneficial. He combines microscopy and genetic approaches to elucidate the molecular basis of host responses to microbial colonization and to dissect the effects of specific microbial species to the health of the host.

Abstract
Every step of vertebrate evolution has occurred in close association with microbes. Thus, it should not come as a surprise that most aspects of vertebrate physiology, including immune regulation, are influenced by interactions with microbes. But the subject is technically challenging to address and the host pathways mediating changes in immune states elicited by intestinal microbial colonization remain incompletely characterized. This talk will explain how zebrafish embryos may be utilized as a convenient model to assess effects of colonizing microbes on the host, and briefly describe the discovery of an unexpected suppressive action on the expression of a component of host immune regulation.

Read more about the lecture series This Week's Discoveries

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