Universiteit Leiden

nl en


Afscheidssymposium Prof. dr. M. Danhof: "Four decades of Research in Pharmacokinetics, Pharmacodynamics and beyond...",

31 maart 2017
Breestraat 60
2311 CS Leiden
Stadsgehoorzaal, Academiegebouw Universiteit Leiden

Dit afscheidssymposium viert de professionele carrière van Prof.dr. Danhof en al zijn bijdragen op hoog niveau aan het vakgebied Farmacologie. Na het symposium volgt het afscheidscollege van Professor Danhof met aansluitend een receptie.

Voor vragen: symposium@lacdr.leidenuniv.nl

Bezoek de officiële symposium website hier >


Voor het symposium en het afscheidscollege dient u zich apart te registeren:

Er zijn geen kosten aan de registratie verbonden.

De registratie voor het symposium is gesloten.

Wanneer u onverhoopt verhinderd bent voor het symposium nadat u zich heeft geregistreerd, vragen wij u dit ons te laten weten.


Symposium Programma, Stadsgehoorzaal


  • Prof. dr. Douwe Breimer - Universiteit Leiden, NL

  • Prof. dr. Catherijne Knibbe - Antonious Ziekenhuis Nieuwegein / Universiteit Leiden, NL

09:00 - 09:30 Welcome with coffee & tea at "Stadsgehoorzaal"

09:30 - 09:40 Introduction pharmacokinetics - pharmacodynamics research at Leiden University

Douwe Breimer - Leiden University, NL

09:40 - 10:00 Pharmacokinetics: from physiologically-based models to compartmental models and back!

Amin Rostami - University of Manchester, UK

10:00 - 10:20 Targeting the CNS; translational research approaches

Elizabeth de Lange - Leiden University, NL

10:20 - 10:40 Measuring and modeling pharmacological drug effect: Mission Accomplished!!!

Don Stanski - AstraZeneca, USA

10:40 - 11:10 COFFEE BREAK

11:10 - 11:30 Quantitative translational pharmacology: connecting pharmacokinetics, dynamics and receptor theory

Piet Hein van der Graaf - Leiden University, NL/Certara, UK

11:30 - 11:50 Drug development as easy as (phase) I II III IV ? Time for disruption!

Adam Cohen - Center for Human Drug Research (CHDR), NL

11:50 - 12:10 Drug action in developing biological systems- clinical pharmacology in pediatrics

Sander Vinks - University of Cincinnati, USA

12:10 - 13:30 LUNCH

13:30 - 13:50 Disease and disease progression

Nick Holford - University of Auckland NZL

13:50 - 14:10 Open innovation: towards the sharing of data, models and workflows

Mats Karlsson - Uppsala University, SWE

14:10 - 14:30 Towards systems pharmacology

Don Mager - University of Buffalo, USA

14:30 - 14:50 Precision medicine in clinical practice

Henk Jan Guchelaar - Leiden University Medical Center (LUMC), NL

14:50 - 15:15 COFFEE BREAK

Afscheidscollege, 'Academiegebouw'

15:15 - 15:45 Walk to "Academiegebouw"

16:00 - 17:00 Farewell Lecture: Reflections on pharmacology - Four decades of pharmacokinetics-pharmacodynamics research at Leiden University

Meindert Danhof

17:00 - 18:30 Reception

Voor vragen: symposium@lacdr.leidenuniv.nl



Reflections on pharmacology

“Pharmacokinetics & Pharmacodynamics” en route to “Systems Pharmacology”


Over the years pharmacology has contributed important pharmacokinetic (PK) and pharmacodynamic (PD) modeling concepts that are widely utilized in drug discovery & development research and in clinical practice. At this symposium we will review the established as well as the emerging novel concepts in pharmacology.

At the level of the pharmacodynamics, between 1960 to 1970, the development of receptor theory concepts has yielded the basis for the understanding of in vivo drug-concentration-effect relations. Next, in particular progress in the pharmacokinetics has been the source of novel concepts. Major achievements in pharmacokinetics include: i) the elucidation of the molecular mechanisms of drug disposition (i.e. drug metabolizing enzymes and transporters), ii) the development of pharmacokinetic modeling concepts including the introduction of physiology-based pharmacokinetic (PBPK) modeling for the prediction of in vivo drug concentration profiles, iii) the identification of inter-individual variation in drug disposition as the basis for variation in drug response (and the introduction of the concepts of “population” pharmacokinetics), and iv) the introduction of pharmacokinetic-pharmacodynamic modeling (PKPD) concepts as the basis for prediction of the time course of drug effects.

Nowadays pharmacokinetic and pharmacodynamic modeling concepts are routinely used as the basis for the development of new drugs. Moreover PKPD modeling has become a standard requirement for the regulatory approval of a drug. Yet new concepts continue to emerge. The most recent developments in pharmacology are directed to the interfacing with systems biology. Novel Systems Pharmacology concepts are introduced, which yield a scientific basis for the design, the development and the clinical usage of ‘precision treatments’ aimed at disease modification. 



The symposium is organized by LACDR,

under the auspices of the EUFEPS and FIP.

Deze website maakt gebruik van cookies. Meer informatie